Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study.
Identifieur interne : 000725 ( Main/Exploration ); précédent : 000724; suivant : 000726Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study.
Auteurs : Michael J. Overman [États-Unis] ; Ray Mcdermott [Irlande (pays)] ; Joseph L. Leach [États-Unis] ; Sara Lonardi [Italie] ; Heinz-Josef Lenz [États-Unis] ; Michael A. Morse [États-Unis] ; Jayesh Desai [Australie] ; Andrew Hill [Australie] ; Michael Axelson [États-Unis] ; Rebecca A. Moss [États-Unis] ; Monica V. Goldberg [États-Unis] ; Z Alexander Cao [États-Unis] ; Jean-Marie Ledeine [Belgique] ; Gregory A. Maglinte [États-Unis] ; Scott Kopetz [États-Unis] ; Thierry André [France]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps monoclonaux (usage thérapeutique), Antinéoplasiques (usage thérapeutique), Carcinomes (génétique), Carcinomes (secondaire), Carcinomes (traitement médicamenteux), Femelle, Humains, Instabilité des microsatellites, Mâle, Récepteur-1 de mort cellulaire programmée (antagonistes et inhibiteurs), Réparation de mésappariement de l'ADN, Résultat thérapeutique, Survie sans rechute, Tumeurs colorectales (anatomopathologie), Tumeurs colorectales (génétique), Tumeurs colorectales (mortalité).
- MESH :
- anatomopathologie : Tumeurs colorectales.
- antagonistes et inhibiteurs : Récepteur-1 de mort cellulaire programmée.
- génétique : Carcinomes, Tumeurs colorectales.
- mortalité : Tumeurs colorectales.
- secondaire : Carcinomes.
- traitement médicamenteux : Carcinomes.
- usage thérapeutique : Anticorps monoclonaux, Antinéoplasiques.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Instabilité des microsatellites, Mâle, Réparation de mésappariement de l'ADN, Résultat thérapeutique, Survie sans rechute.
English descriptors
- KwdEn :
- Adult, Antibodies, Monoclonal (therapeutic use), Antineoplastic Agents (therapeutic use), Carcinoma (drug therapy), Carcinoma (genetics), Carcinoma (secondary), Colorectal Neoplasms (genetics), Colorectal Neoplasms (mortality), Colorectal Neoplasms (pathology), DNA Mismatch Repair, Disease-Free Survival, Female, Humans, Male, Microsatellite Instability, Middle Aged, Programmed Cell Death 1 Receptor (antagonists & inhibitors), Treatment Outcome.
- MESH :
- chemical , antagonists & inhibitors : Programmed Cell Death 1 Receptor.
- chemical , therapeutic use : Antibodies, Monoclonal, Antineoplastic Agents.
- drug therapy : Carcinoma.
- genetics : Carcinoma, Colorectal Neoplasms.
- mortality : Colorectal Neoplasms.
- pathology : Colorectal Neoplasms.
- secondary : Carcinoma.
- Adult, DNA Mismatch Repair, Disease-Free Survival, Female, Humans, Male, Microsatellite Instability, Middle Aged, Treatment Outcome.
Abstract
Metastatic DNA mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) colorectal cancer has a poor prognosis after treatment with conventional chemotherapy and exhibits high levels of tumour neoantigens, tumour-infiltrating lymphocytes, and checkpoint regulators. All of these features are associated with the response to PD-1 blockade in other tumour types. Therefore, we aimed to study nivolumab, a PD-1 immune checkpoint inhibitor, in patients with dMMR/MSI-H metastatic colorectal cancer.
DOI: 10.1016/S1470-2045(17)30422-9
PubMed: 28734759
Affiliations:
- Australie, Belgique, France, Irlande (pays), Italie, États-Unis
- Californie, Caroline du Nord, Minnesota, New Jersey, Texas, Île-de-France
- Paris
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Merge: 004B66
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Le document en format XML
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Overman</name><affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: moverman@mdanderson.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Mcdermott, Ray" sort="Mcdermott, Ray" uniqKey="Mcdermott R" first="Ray" last="Mcdermott">Ray Mcdermott</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's University Hospital and Cancer Trials Ireland, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>St Vincent's University Hospital and Cancer Trials Ireland, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Leach, Joseph L" sort="Leach, Joseph L" uniqKey="Leach J" first="Joseph L" last="Leach">Joseph L. Leach</name><affiliation wicri:level="2"><nlm:affiliation>Allina Health System, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Allina Health System, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Lonardi, Sara" sort="Lonardi, Sara" uniqKey="Lonardi S" first="Sara" last="Lonardi">Sara Lonardi</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Oncologico Veneto IOV-IRCSS, Padova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Oncologico Veneto IOV-IRCSS, Padova</wicri:regionArea><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Lenz, Heinz Josef" sort="Lenz, Heinz Josef" uniqKey="Lenz H" first="Heinz-Josef" last="Lenz">Heinz-Josef Lenz</name><affiliation wicri:level="2"><nlm:affiliation>USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>USC Norris Comprehensive Cancer Center, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Morse, Michael A" sort="Morse, Michael A" uniqKey="Morse M" first="Michael A" last="Morse">Michael A. Morse</name><affiliation wicri:level="2"><nlm:affiliation>Duke University Medical Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Desai, Jayesh" sort="Desai, Jayesh" uniqKey="Desai J" first="Jayesh" last="Desai">Jayesh Desai</name><affiliation wicri:level="1"><nlm:affiliation>Royal Melbourne Hospital/Peter MacCallum Cancer Centre, Victoria, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Melbourne Hospital/Peter MacCallum Cancer Centre, Victoria, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Andrew" sort="Hill, Andrew" uniqKey="Hill A" first="Andrew" last="Hill">Andrew Hill</name><affiliation wicri:level="1"><nlm:affiliation>Tasman Oncology Research Ltd, Southport, Queensland, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Tasman Oncology Research Ltd, Southport, Queensland, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Axelson, Michael" sort="Axelson, Michael" uniqKey="Axelson M" first="Michael" last="Axelson">Michael Axelson</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Moss, Rebecca A" sort="Moss, Rebecca A" uniqKey="Moss R" first="Rebecca A" last="Moss">Rebecca A. Moss</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Goldberg, Monica V" sort="Goldberg, Monica V" uniqKey="Goldberg M" first="Monica V" last="Goldberg">Monica V. Goldberg</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Cao, Z Alexander" sort="Cao, Z Alexander" uniqKey="Cao Z" first="Z Alexander" last="Cao">Z Alexander Cao</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Ledeine, Jean Marie" sort="Ledeine, Jean Marie" uniqKey="Ledeine J" first="Jean-Marie" last="Ledeine">Jean-Marie Ledeine</name><affiliation wicri:level="1"><nlm:affiliation>Bristol-Myers Squibb, Braine-L'Alleud, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Bristol-Myers Squibb, Braine-L'Alleud</wicri:regionArea><wicri:noRegion>Braine-L'Alleud</wicri:noRegion></affiliation></author><author><name sortKey="Maglinte, Gregory A" sort="Maglinte, Gregory A" uniqKey="Maglinte G" first="Gregory A" last="Maglinte">Gregory A. Maglinte</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Kopetz, Scott" sort="Kopetz, Scott" uniqKey="Kopetz S" first="Scott" last="Kopetz">Scott Kopetz</name><affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Andre, Thierry" sort="Andre, Thierry" uniqKey="Andre T" first="Thierry" last="André">Thierry André</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint Antoine, Assistance Publique Hôpitaux de Paris and Sorbonne Universités, UMPC Paris 06, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint Antoine, Assistance Publique Hôpitaux de Paris and Sorbonne Universités, UMPC Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Monoclonal (therapeutic use)</term><term>Antineoplastic Agents (therapeutic use)</term><term>Carcinoma (drug therapy)</term><term>Carcinoma (genetics)</term><term>Carcinoma (secondary)</term><term>Colorectal Neoplasms (genetics)</term><term>Colorectal Neoplasms (mortality)</term><term>Colorectal Neoplasms (pathology)</term><term>DNA Mismatch Repair</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Male</term><term>Microsatellite Instability</term><term>Middle Aged</term><term>Programmed Cell Death 1 Receptor (antagonists & inhibitors)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Antinéoplasiques (usage thérapeutique)</term><term>Carcinomes (génétique)</term><term>Carcinomes (secondaire)</term><term>Carcinomes (traitement médicamenteux)</term><term>Femelle</term><term>Humains</term><term>Instabilité des microsatellites</term><term>Mâle</term><term>Récepteur-1 de mort cellulaire programmée (antagonistes et inhibiteurs)</term><term>Réparation de mésappariement de l'ADN</term><term>Résultat thérapeutique</term><term>Survie sans rechute</term><term>Tumeurs colorectales (anatomopathologie)</term><term>Tumeurs colorectales (génétique)</term><term>Tumeurs colorectales (mortalité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Programmed Cell Death 1 Receptor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antineoplastic Agents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Récepteur-1 de mort cellulaire programmée</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma</term><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinomes</term><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Carcinomes</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Carcinoma</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinomes</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Antinéoplasiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>DNA Mismatch Repair</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Male</term><term>Microsatellite Instability</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Instabilité des microsatellites</term><term>Mâle</term><term>Réparation de mésappariement de l'ADN</term><term>Résultat thérapeutique</term><term>Survie sans rechute</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Metastatic DNA mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) colorectal cancer has a poor prognosis after treatment with conventional chemotherapy and exhibits high levels of tumour neoantigens, tumour-infiltrating lymphocytes, and checkpoint regulators. All of these features are associated with the response to PD-1 blockade in other tumour types. Therefore, we aimed to study nivolumab, a PD-1 immune checkpoint inhibitor, in patients with dMMR/MSI-H metastatic colorectal cancer.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li><li>Irlande (pays)</li><li>Italie</li><li>États-Unis</li></country><region><li>Californie</li><li>Caroline du Nord</li><li>Minnesota</li><li>New Jersey</li><li>Texas</li><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Overman, Michael J" sort="Overman, Michael J" uniqKey="Overman M" first="Michael J" last="Overman">Michael J. Overman</name></region><name sortKey="Axelson, Michael" sort="Axelson, Michael" uniqKey="Axelson M" first="Michael" last="Axelson">Michael Axelson</name><name sortKey="Cao, Z Alexander" sort="Cao, Z Alexander" uniqKey="Cao Z" first="Z Alexander" last="Cao">Z Alexander Cao</name><name sortKey="Goldberg, Monica V" sort="Goldberg, Monica V" uniqKey="Goldberg M" first="Monica V" last="Goldberg">Monica V. Goldberg</name><name sortKey="Kopetz, Scott" sort="Kopetz, Scott" uniqKey="Kopetz S" first="Scott" last="Kopetz">Scott Kopetz</name><name sortKey="Leach, Joseph L" sort="Leach, Joseph L" uniqKey="Leach J" first="Joseph L" last="Leach">Joseph L. Leach</name><name sortKey="Lenz, Heinz Josef" sort="Lenz, Heinz Josef" uniqKey="Lenz H" first="Heinz-Josef" last="Lenz">Heinz-Josef Lenz</name><name sortKey="Maglinte, Gregory A" sort="Maglinte, Gregory A" uniqKey="Maglinte G" first="Gregory A" last="Maglinte">Gregory A. Maglinte</name><name sortKey="Morse, Michael A" sort="Morse, Michael A" uniqKey="Morse M" first="Michael A" last="Morse">Michael A. Morse</name><name sortKey="Moss, Rebecca A" sort="Moss, Rebecca A" uniqKey="Moss R" first="Rebecca A" last="Moss">Rebecca A. Moss</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Mcdermott, Ray" sort="Mcdermott, Ray" uniqKey="Mcdermott R" first="Ray" last="Mcdermott">Ray Mcdermott</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Lonardi, Sara" sort="Lonardi, Sara" uniqKey="Lonardi S" first="Sara" last="Lonardi">Sara Lonardi</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Desai, Jayesh" sort="Desai, Jayesh" uniqKey="Desai J" first="Jayesh" last="Desai">Jayesh Desai</name></noRegion><name sortKey="Hill, Andrew" sort="Hill, Andrew" uniqKey="Hill A" first="Andrew" last="Hill">Andrew Hill</name></country><country name="Belgique"><noRegion><name sortKey="Ledeine, Jean Marie" sort="Ledeine, Jean Marie" uniqKey="Ledeine J" first="Jean-Marie" last="Ledeine">Jean-Marie Ledeine</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Andre, Thierry" sort="Andre, Thierry" uniqKey="Andre T" first="Thierry" last="André">Thierry André</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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